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Lists for Combinations of Hazard Endpoints

Specified Lists for Combinations - DRAFT ONLY (Dec, 2009)

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NIOSH Authoritative A Occupational Cancer H 1
NTP-C Authoritative A Known to be a human carcinogen H 1
NTP-C Authoritative A Reasonably Anticipated to be a human carcinogen H 1
NTP-C Authoritative A Chemicals of high concern H 1
SVHC Authoritative A Extremely Hazardous Substance, may be Green Screen vH or H vH 1
IRIS (1999, 2005) Authoritative A Carcinogenic to humans H 1
IRIS (1999, 2005) Authoritative A Likely to be carcinogenic to humans H 1
IRIS (2005) Authoritative B Suggestive evidence of carcinogenic potential M 2
IRIS (1999, 2005) Authoritative A Not likely to be carcinogenic to humans L N/A
IRIS (1999) Authoritative B Suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential M 2
IRIS (1996) Authoritative A Known/likely human carcinogen H 1
IRIS (1986) Authoritative A Group A - Human Carcinogen H 1
IRIS (1986) Authoritative A Group B1 - Probably human carcinogen H 1
IRIS (1986) Authoritative A Group B2 - Probably human carcinogen H 1
IRIS (1986) Authoritative B Group C - “Possible human carcinogen” M 2
IRIS (1986) Reference   Group D – “Not classifiable as to human carcinogenicity”? (can be either not likely or a data gap) Unknown  
IRIS (1986) Authoritative A Group E - “Evidence of non-carcinogenicity to humans” L N/A
IARC Authoritative A Group 1: Agent is carcinogenic to humans H 1
IARC Authoritative A Group 2A: Agent is probably carcinogenic to humans H 1
IARC Authoritative B Group 2b: Possibly carcinogenic to humans M 2
IARC Reference   Group 3: Not classifiable as to carcinogenicity to humans Unknown N/A
IARC Authoritative A Group 4: Probably not carcinogenic to humans L N/A
PROP 65 Authoritative A Known to the state to cause cancer H 1
PROP 65 Authoritative A Known to the state to cause reproductive effects H 1
EU CMR List Authoritative A Carcinogen Category 1: “known” H 1
EU CMR List Authoritative A Carcinogen Category 2: “should be considered carcinogenic to humans” H 1
EU CMR List Authoritative B Carcinogen Category 3: “possibly carcinogenic to humans” (listed as Carc. Cat. 3) M 2
EU CMR List Authoritative A Mutagen Category 1: “Substances known to be mutagenic to man” H 1
EU CMR List Authoritative A Mutagen Category 2: “Substances which should be regarded as if they are mutagenic to man” H 1
EU CMR List Authoritative B Mutagen Category 3: Possible M 2
EU CMR List Authoritative A Reproduction Category 1: “known” to impair fertility in humans or cause developmental toxicity in humans” H 1
EU CMR List Authoritative A Reproduction Category 2: “should be regarded as if” they impair fertility to humans or cause developmental toxicity to humans” H 1
EU CMR List Authoritative B Reproduction Category 3: possible M 2
G&L Screening A Developmental Neurotoxicant H 1
G&L Screening A Neurotoxicant M 2
EU ED Screening A Category 1 (“at least one in-vivo study providing clear evidence for endocrine disruption in at least one species using intact animals”), H 2
EU ED Screening A Category 2 (“Potential for endocrine disruption. In-vitro data indicating potential for endocrine disruption in intact organisms. Also includes effects in-vivo that may, or may not, be ED-mediated.”) M 2
EU ED Screening B Category 3a (“No scientific basis for inclusion in list; ED Studies available but no indication of ED effects" L  
EU ED Reference   Category 3b (“Substances with no or insufficient data gathered") Unknown  
EU DSD Authoritative A R45 “May cause cancer” H 1
EU DSD Authoritative A R49 “May cause cancer by inhalation” H 1
EU DSD Authoritative B R40 “Limited Evidence of Carcinogenic Effects” M 2
EU DSD Authoritative A R46 “May cause heritable genetic damage“ H 1
EU DSD Authoritative B R68 “May cause irreversible effects“ M 2
EU DSD Authoritative A R60 “May impair fertility” H 1
EU DSD Authoritative A R61 “May cause harm to the unborn child” H 1
EU DSD Authoritative B R62 “Possible risk of impaired fertility” M 2
EU DSD Authoritative B R63 “Possible risk of harm to the unborn child” M 2
EU DSD Authoritative B R64 “May cause harm to breastfed babies” M 2
EU DSD Authoritative A R28 “Very Toxic if Swallowed” vH 1
EU DSD Authoritative A R27 “Very Toxic in Contact with Skin” vH 1
EU DSD Authoritative A R26 “Very Toxic by Inhalation” vH 1
EU DSD Authoritative B R25 “Toxic if Swallowed”; May be Green Screen vH or H vH 1
EU DSD Authoritative B  R24 “Toxic in Contact with Skin”; May be Green Screen vH or H vH 1
EU DSD Authoritative B R23 “Toxic by Inhalation”; May be Green Screen vH or H vH 1
EU DSD Authoritative B  R22 “Harmful if Swallowed”; May be Green Screen H or M H 2
EU DSD Authoritative B R21 “Harmful in Contact with Skin”;May be Green Screen H or M H 2
EU DSD Authoritative A R34 “Causes burns” H 2
EU DSD Authoritative A R35 “Causes severe burns” H 2
EU DSD Authoritative A R41 “Risk of serious damage to eyes” H 2
EU DSD Authoritative A R38 “Irritating to skin” M 4
EU DSD Authoritative B R36 “Irritating to eyes”; May be Green Screen M or L M 4
EU DSD Authoritative A R42 “May cause sensitization by inhalation” H 2
EU DSD Authoritative B R43 “May cause sensitization by skin contact”; May be Green Screen H or M H 2
EU DSD Authoritative A R39/26 “Very Toxic: Danger of very serious irreversible effects through inhalation.” vH 1
EU DSD Authoritative A R39/27 “Very Toxic: Danger of very serious irreversible effects in contact with skin.” vH 1
EU DSD Authoritative A R39/28 “Very Toxic: Danger of very serious irreversible effects if swallowed.” vH 1
EU DSD Authoritative A R39/23 “Toxic: Danger of very serious irreversible effects through inhalation.” vH 1
EU DSD Authoritative A R39/24 “Toxic: Danger of very serious irreversible effects in contact with skin.” vH 1
EU DSD Authoritative A R39/25 “Toxic: Danger of very serious irreversible effects if swallowed.” vH 1
EU DSD Authoritative A R48/23 “Toxic: Danger of Serious Damage to health by prolonged exposure through inhalation.” H 2
EU DSD Authoritative A R48/24 “Toxic: Danger of Serious Damage to health by prolonged exposure in contact with skin.” H 2
EU DSD Authoritative A R48/25 “Toxic: Danger of Serious Damage to health by prolonged exposure if swallowed.” H 2
EU DSD Authoritative A R48 with combinations of R23-25 H 2
EU DSD Authoritative A R68/20 “Harmful: Possible risk of irreversible effects through inhalation.” H 2
EU DSD Authoritative A R68/21 “Harmful: Possible risk of irreversible effects in contact with skin.” H 2
EU DSD Authoritative A R68/22 “Harmful: Possible risk of irreversible effects if swallowed.” H 2
EU DSD Authoritative A R48/20 “Harmful: Danger of Serious Damage to health by prolonged exposure through inhalation.” M 4
EU DSD Authoritative A R48/21 “Harmful: Danger of Serious Damage to health by prolonged exposure in contact with skin.” M 4
EU DSD Authoritative A R48/22 “Harmful: Danger of Serious Damage to health by prolonged exposure if swallowed.” M 4
EU DSD Authoritative A R48 with combinations of R20-22 M 4
EU DSD Authoritative A R67 “Vapors may cause drowsiness and dizziness” M 4
EU DSD Authoritative A R12 “Extremely Flammable” (liquid only) vH 2
EU DSD Authoritative B R10 “Flammable” (liquid); May be Green Screen vH, H, or M depending on flashpoint and initial boiling point (liquid). vH 2
EU DSD Authoritative B R11 “Highly flammable” (liquid, solid); May be Green Screen vH or H depending on initial boiling point (liquid). No direct translation possible for solid. vH 2
EU DSD Authoritative B R12 “Extremely flammable” (gas); May be Green Screen H or M H 2
EU DSD Authoritative A R50/53 "Very Toxic to Aquatic Organisms, May cause long-term adverse effects in the aquatic environment" vH 1
EU DSD Authoritative A R51/53 Toxic to Aquatic Organisms, May cause long-term adverse effects in the aquatic environment H 2
EU DSD Authoritative A R52/53 Harmful to Aquatic Organisms, May cause long-term adverse effects in the aquatic environment M 3
EU DSD Authoritative A R50 "Very Toxic to Aquatic Organisms" vH 1
EU DSD Authoritative A R51"Toxic to Aquatic Organisms" H 2
EU DSD Authoritative A R52 "Harmful to Aquatic Organisms" M 4
DSL Screening A B vH  
DSL Screening A iT non-human (based on eco T acute ) vH 1
DSL Reference   iT non-human (based on eco T chronic) Unknown Unknown
WHMIS Screening A B1 Flammable Gas.  H 2
WHMIS Screening B B2 Flammable Liquid. May be Green Screen vH or H or M. vH 1
WHMIS Screening A B3 Combustible Liquid M 4
WHMIS Reference   B4 Flammable Solid Unknown Unknown
WHMIS Screening B D1A Toxic - Immediate, Serious. May be Green Screen vH or H vH 1
WHMIS Screening B D1B Toxic - Immeciate, Serious. May be Green Screen vH or H or M. vH 1
WHMIS Reference   E - Corrosive Unknown Unknown
OSPAR Reference   Endocrine Disruptor Unknown  
List Abbreviation List Type   List Category Green Screen Hazards Green Screen Benchmark
Stolkholm Authoritative A POP PBT 1
TRI PBT Authoritative A PBT PBT 1
EPA PBT Authoritative A PBT PBT 1
NWMP Authoritative A PBT PBT 1
ESIS PBT Authoritative A PBT PBT 1
ESIS PBT Authoritative A vPvB vPvB 1
WA PBT Authoritative A PBT PBT 1
DSL Screening A PBiT non-human PBT 1
DSL Screening A PBiT human PBT 1
VwVwS Reference   Class 3 or 2 or 1 or 0 Any combination of the following: Acute Toxicity, Systemic/Organ, Carcinogenicity, Repro/Dev, Acute aquatic Toxicity, Chronic Aquatic Toxicity, Persistence, Bioaccumulation Unknown
DSL Reference   iT human Carcinogenicity, Mutagenicity, Repro/Dev, Acute Toxicity, System/Organ Unknown
WHMIS Reference   D2 Toxic - With other effects Chronic Human Health Effects: C,M,R,Sensitization, Systemic/Organ, skin/eye irritation Unknown
OSPAR Reference   PBT Persistence, Bioaccumulation, Acute Aquatic Toxicity, Chronic Aquatic Toxicity, Carcinogenicity, Mutagenicity, Reproductive/Developmental Toxicity, Chronic mammalian toxicity Unknown
OR PBT Reference   Persistent Pollutants Toxicity and Persistence and/or Bioaccumulation; Toxicity includes Aquatic Toxicity and/or Toxicity to Humans Unknown

See definitions for list abbreviations


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