Human Health Hazard Threshold Values

Carcinogenicity*

Recommended Test Methods and Models

· GHS Category 1A or 1B

· Authoritative and/or Screening Lists

· GHS Category 2

· Authoritative and/or Screening Lists

· Meets DfE General Screen Criteria for Carcinogenicity

· Authoritative and/or Screening Lists

Mutagenicity/Genotoxicity*

· GHS Category 1A or 1B

· Authoritative and/or Screening Lists

· GHS Category 2

· Authoritative and/or Screening Lists

· Meets DfE General Screen Criteria for Genetic Toxicity

Reproductive/Developmental toxicity*

· GHS Category 1A or 1B

· Authoritative and/or Screening Lists

· GHS Category 2 or Effects on Lactation

· Authoritative and/or Screening Lists

· Meets DfE General Screen Criteria for Reproductive and Developmental Toxicity

Endocrine Disruption*

· Weight of evidence demonstrates possible endocrine system mediated effects and high potency

· Screening List

· Weight of evidence demonstrates possible endocrine system mediated effect that are lower potency and/or reversible effects

· Screening List

· Meets DfE General Screen for each endpoint related to an endocrine system mediated effect (e.g. carcinogenicity, reproductive/developmental toxicity, repeated dose toxicity)

· Screening List

· Weight of evidence demonstrates potential for irreversible neurotoxic effects in humans or developmental neurotoxicity in humans

· Screening List

· Weight of evidence demonstrates potential for neurotoxic effects in humans

· Screening List

· Meets DfE General Screen for Neurotoxicity

Acute Mammalian Toxicity (oral, dermal and inhalation)

Recommended Test Methods and Models

· GHS Category 1 or 2

Authoritative and/or Screening Lists

· GHS Category 3

· Authoritative and/or Screening Lists

· GHS Category 4

· Authoritative and/or Screening Lists

· Meets DfE General Screen for Acute Mammalian Toxicity

· GHS Category 1 Skin

· GHS Category 1 Eye

· Authoritative and/or Screening Lists

· GHS Category 2 Skin

· GHS Category 2A Eye

· Authoritative and/or Screening Lists

· GHS Category 3 Skin

· GHS Category 2B Eye

· GHS not classifiable

· Authoritative and/or Screening Lists

Sensitization of the Skin or Respiratory System

· GHS Category 1 Respiratory Sensitizer

·  GHS Category 1A Skin Sensitizer

· GHS Category 1B Skin Sensitizer

· Authoritative and/or Screening Lists

· Meets DfE General Screen for Respiratory Sensitization and Skin Sensitization

Systemic Toxicity/Organ Effects (via single or repeated exposure, includes immunotoxicity)

Recommended Test Methods and Models for Single Exposure, Repeated Exposure, Immunotoxicity

· GHS Category 1 single exposure

· Authoritative and/or Screening Lists

· GHS Category 2 single exposure

· GHS Category 1 repeated exposure

· Authoritative and/or Screening Lists

· GHS Category 3 single exposure

· GHS Category 2 repeated exposure

· Authoritative and/or Screening Lists

· Meets DfE General Screen for Repeated Dose Toxicity. Must include evaluation of immune system effects.

· Not classifiable for GHS organ toxicity single exposure or repeated exposure.